The KO Validated HB-EGF Rabbit Monoclonal Antibody is a powerful tool for researchers studying HB-EGF, a key growth factor involved in various cellular processes, including cell proliferation, migration, and differentiation. This monoclonal antibody, developed using rabbit-derived cells, is highly specific and sensitive for detecting HB-EGF in human samples.Validated for use in Western blot applications, this antibody binds specifically to the HB-EGF protein, allowing for precise detection and analysis in a variety of cell types. Its high reactivity and specificity make it an ideal choice for studies in cell biology, signal transduction, and cancer research.
HB-EGF is known for its role in promoting cell growth and survival, making it a potential target for therapeutic interventions in conditions such as cancer and heart disease. Research into the function and regulation of HB-EGF is crucial for developing new treatments that target this growth factor, offering hope for improved outcomes for patients with these challenging diseases. The KO Validated HB-EGF Rabbit Monoclonal Antibody is a valuable tool for advancing our understanding of HB-EGF biology and exploring its potential as a therapeutic target.
Product Name:
[KO Validated] HB-EGF Rabbit Monoclonal Antibody
SKU:
CAB11657
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human HB-EGF (Q99075).
Cell membrane, Secreted, Single-pass type I membrane protein, extracellular space.
Calculated MW:
23kDa
Observed MW:
18-28kDa
Enables growth factor activity and heparin binding activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of protein kinase B signaling; and positive regulation of wound healing. Located in cell surface and extracellular space. Implicated in glomerulosclerosis and perinatal necrotizing enterocolitis.
Purification Method:
Affinity purification
Gene ID:
1839
Clone Number:
ARC0663
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using HB-EGF antibody (CAB11657) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
