The GSK3alpha Polyclonal Antibody (CAB18655) is a crucial tool for researchers exploring the role of glycogen synthase kinase 3 alpha (GSK3alpha) in various cellular processes. This antibody, produced in rabbits, has been validated for use in Western blot applications and is highly reactive with human samples. By specifically binding to the GSK3alpha protein, this antibody allows for precise detection and analysis in a wide range of cell types.GSK3alpha is a key enzyme involved in numerous cellular processes, including cell growth, differentiation, and apoptosis. Dysregulation of GSK3alpha has been implicated in various diseases, making it an attractive target for research in areas such as cancer, neurodegenerative disorders, and diabetes.
By understanding the activity and regulation of GSK3alpha, researchers can gain valuable insights into disease mechanisms and potentially identify novel therapeutic strategies.Overall, the GSK3alpha Polyclonal Antibody is a valuable tool for scientists studying the complex functions of GSK3alpha in health and disease. Its high specificity and sensitivity make it an essential component of any research project aiming to elucidate the intricate role of GSK3alpha in cellular physiology.
Product Name:
[KO Validated] GSK3α Rabbit Polyclonal Antibody
SKU:
CAB18655
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 400-483 of human GSK3α (NP_063937.2).
This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease.
Purification Method:
Affinity purification
Gene ID:
2931
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and GSK3α knockout (KO) HeLa cells, using [KO Validated] GSK3α Rabbit pAb (18655) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
