The GRK2 Rabbit Monoclonal Antibody (CAB4443) is a powerful tool for researchers studying G protein-coupled receptor kinase 2 (GRK2) in various cellular processes. This antibody, produced in rabbits, is highly specific and sensitive for detecting GRK2 protein levels in human samples, making it an ideal choice for Western blot applications.GRK2 is a key regulator of G protein-coupled receptor signaling, playing a critical role in processes such as cell migration, proliferation, and signal transduction. Dysregulation of GRK2 has been implicated in various diseases, including heart failure, hypertension, and cancer.
By targeting GRK2 with this antibody, researchers can gain valuable insights into the role of this protein in health and disease.With its high reactivity and specificity, the GRK2 Rabbit Monoclonal Antibody (CAB4443) is a valuable tool for researchers in the fields of molecular biology, biochemistry, and pharmacology. Its ability to accurately detect and measure GRK2 levels in various cell types makes it an essential component of studies aiming to understand the complex mechanisms underlying cellular signaling pathways.
Product Name:
[KO Validated] GRK2 Rabbit Monoclonal Antibody
SKU:
CAB4443
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 590-689 of human GRK2 (P25098).
This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease.
Purification Method:
Affinity purification
Gene ID:
156
Clone Number:
ARC1013
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using GRK2 Rabbit mAb (CAB4443) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
