The KO Validated GLUL Polyclonal Antibody (CAB5437) is a cutting-edge tool for researchers studying the GLUL protein, which plays a key role in glutamine metabolism and regulation of cell growth and proliferation. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it a reliable choice for Western blot applications.GLUL, also known as glutamine synthetase, is involved in the conversion of glutamate to glutamine, a process essential for various cellular functions, including energy production and neurotransmission.
Dysregulation of GLUL has been implicated in conditions such as cancer, neurodegenerative diseases, and metabolic disorders, highlighting its potential as a therapeutic target.With the KO Validated GLUL Polyclonal Antibody, researchers can accurately detect and quantify GLUL expression in different cell types, paving the way for insights into the role of glutamine metabolism in disease pathogenesis and potential treatment strategies. This antibody is a valuable tool for investigations in areas such as oncology, neurobiology, and metabolic disorders.
The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
2752
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Glutamine Synthetase (GLUL) Rabbit pAb (CAB5437) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
