[KO Validated] FGF2 Rabbit Monoclonal Antibody (CAB11488)
- SKU:
- CAB11488
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cardiovascular
Description
Product Name: | [KO Validated] FGF2 Rabbit Monoclonal Antibody |
SKU: | CAB11488 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human FGF2 (NP_001997.5). |
Sequence: | RAPE RVGG RGRG RGTA APRA APAA RGSR PGPA GTMA AGSI TTLP ALPE DGGS GAFP PGHF KDPK RLYC KNGG FFLR IHPD GRVD GVRE KSDP HIKL QLQA E |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:100 - 1:500 IF/ICC,1:50 - 1:200 |
Synonyms: | BFGF; FGFB; FGF-2; HBGF-2; F2 |
Positive Sample: | SKOV3 |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus, Secreted. |
Calculated MW: | 31kDa |
Observed MW: | 18kDa/22kDa/31kDa |
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF.
Purification Method: | Affinity purification |
Gene ID: | 2247 |
Clone Number: | ARC0618 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |