[KO Validated] Fascin/FSCN1 Rabbit Polyclonal Antibody (CAB1904)
- SKU:
- CAB1904
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | [KO Validated] Fascin/FSCN1 Rabbit Polyclonal Antibody |
SKU: | CAB1904 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 394-493 of human Fascin/Fascin/FSCN1 (NP_003079.1). |
Sequence: | FIGC RKVT GTLD ANRS SYDV FQLE FNDG AYNI KDST GKYW TVGS DSAV TSSG DTPV DFFF EFCD YNKV AIKV GGRY LKGD HAGV LKAS AETV DPAS LWEY |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | HSN; SNL; p55; FAN1; N1 |
Positive Sample: | U-251MG,HeLa,NCI-H460,HepG2,SH-SY5Y,Mouse brain,Mouse spinal cord |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell projection, Cytoplasm, cytoskeleton, cytosol, filopodium, invadopodium, microvillus. |
Calculated MW: | 55kDa |
Observed MW: | 50kDa, 55kDa |
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15.
Purification Method: | Affinity purification |
Gene ID: | 6624 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |