The KO Validated Fascin Polyclonal Antibody (CAB1904) is a highly specific tool for researchers studying fascin, a key protein involved in cell motility and shape. This antibody, produced in rabbits, has been rigorously tested and validated for use in various applications, particularly immunofluorescence and immunohistochemistry.Fascin is a critical regulator of cell migration and adhesion, playing a vital role in processes such as embryonic development, wound healing, and cancer metastasis. By targeting fascin with this antibody, researchers can investigate its expression and localization in different cell types and tissues, providing valuable insights into its functions and potential roles in disease progression.
With its high specificity and sensitivity, the KO Validated Fascin Polyclonal Antibody offers a reliable tool for analyzing fascin in diverse research areas, including cell biology, cancer biology, and developmental biology. Its validated performance ensures accurate and reproducible results, making it an essential reagent for studies aiming to uncover the mechanisms underlying cell motility and invasion.
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15.
Purification Method:
Affinity purification
Gene ID:
6624
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] Fascin/FSCN1 Rabbit pAb (CAB1904) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
