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[KO Validated] Fascin/FSCN1 Rabbit Polyclonal Antibody (CAB1904)

SKU:
CAB1904
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • KO Validated Antibodies 1 Anti-FSCN1 Antibody CAB1904KO Validated
  • KO Validated Antibodies 1 Anti-FSCN1 Antibody CAB1904KO Validated
  • KO Validated Antibodies 1 Anti-FSCN1 Antibody CAB1904KO Validated
  • KO Validated Antibodies 1 Anti-FSCN1 Antibody CAB1904KO Validated
  • KO Validated Antibodies 1 Anti-FSCN1 Antibody CAB1904KO Validated
$167 - $503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] Fascin/FSCN1 Rabbit Polyclonal Antibody
SKU:CAB1904
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 394-493 of human Fascin/Fascin/FSCN1 (NP_003079.1).
Sequence:FIGC RKVT GTLD ANRS SYDV FQLE FNDG AYNI KDST GKYW TVGS DSAV TSSG DTPV DFFF EFCD YNKV AIKV GGRY LKGD HAGV LKAS AETV DPAS LWEY
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200
Synonyms:HSN; SNL; p55; FAN1; N1
Positive Sample:U-251MG,HeLa,NCI-H460,HepG2,SH-SY5Y,Mouse brain,Mouse spinal cord
Conjugate:Unconjugated
Cellular Localization:Cell junction, Cell projection, Cytoplasm, cytoskeleton, cytosol, filopodium, invadopodium, microvillus.
Calculated MW:55kDa
Observed MW:50kDa, 55kDa

This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15.

Purification Method:Affinity purification
Gene ID:6624
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using [KO Validated] Fascin/FSCN1 Rabbit pAb (CAB1904) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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