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[KO Validated] FANCD2 Rabbit Polyclonal Antibody (CAB18055)

SKU:
CAB18055
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle
€139 - €419
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Description

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[KO Validated] FANCD2 Rabbit Polyclonal Antibody (CAB18055)

The KO-Validated FANCD2 Polyclonal Antibody (CAB18055) is a powerful tool for researchers studying FANCD2, a key protein involved in the Fanconi Anemia pathway and DNA repair processes. This antibody, derived from rabbits, has been rigorously validated for use in various applications, including Western blotting, immunofluorescence, and immunoprecipitation. Its high specificity and sensitivity make it ideal for detecting FANCD2 in human samples, enabling precise and reliable analysis in research focused on DNA damage response and genome stability.FANCD2 is a crucial factor in the cellular response to DNA damage, playing a vital role in maintaining genomic integrity and preventing the accumulation of mutations that can lead to cancer and other diseases.

By targeting FANCD2, researchers can gain valuable insights into the mechanisms underlying DNA repair and the development of potential therapies for genetic disorders and cancer treatment. The KO-Validated FANCD2 Polyclonal Antibody offers a versatile and effective tool for advancing scientific understanding in these critical areas of study.

Product Name:[KO Validated] FANCD2 Rabbit Polyclonal Antibody
SKU:CAB18055
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human FANCD2 (NP_149075.2).
Sequence:MVSK RRLS KSED KESL TEDA SKTR KQPL SKKT KKSH IANE VEEN DSIF VKLL KISG IILK TGES QNQL AVDQ IAFQ KKLF QTLR RHPS YPKI IEEF VSGL ESYI EDED SFRN CLLS CERL QDEE ASMG ASYS KSLI KLLL GIDI LQPA IIKT LFEK LPEY FFEN KNSD EINI PRLI VSQL KWLD RVVD GKDL TTKI MQLI SIAP ENLQ HDII TSLP EILG DSQH ADVG KE
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:FA4; FAD; FACD; FAD2; FA-D2; FANCD; D2
Positive Sample:HeLa
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:164kDa
Observed MW:166kDa

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:2177
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from wild type (WT) and FANCD2 knockout (KO) HeLa cells, using [KO Validated] FANCD2 Rabbit pAb (CAB18055) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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