[KO Validated] FANCD2 Rabbit Polyclonal Antibody (CAB18055)
- SKU:
- CAB18055
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
Product Name: | [KO Validated] FANCD2 Rabbit Polyclonal Antibody |
SKU: | CAB18055 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human FANCD2 (NP_149075.2). |
Sequence: | MVSK RRLS KSED KESL TEDA SKTR KQPL SKKT KKSH IANE VEEN DSIF VKLL KISG IILK TGES QNQL AVDQ IAFQ KKLF QTLR RHPS YPKI IEEF VSGL ESYI EDED SFRN CLLS CERL QDEE ASMG ASYS KSLI KLLL GIDI LQPA IIKT LFEK LPEY FFEN KNSD EINI PRLI VSQL KWLD RVVD GKDL TTKI MQLI SIAP ENLQ HDII TSLP EILG DSQH ADVG KE |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | FA4; FAD; FACD; FAD2; FA-D2; FANCD; D2 |
Positive Sample: | HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 164kDa |
Observed MW: | 166kDa |
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 2177 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |