[KO Validated] ERK2 Rabbit Monoclonal Antibody (CAB19630)
- SKU:
- CAB19630
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
Product Name: | [KO Validated] ERK2 Rabbit Monoclonal Antibody |
SKU: | CAB19630 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human ERK2ERK1/2 (P27361/P28482). |
Sequence: | FLTE YVAT RWYR APEI MLNS KGYT KSID IWSV GCIL AEML SNRP IFPG KHYL DQLN HILG ILGS PSQE DLNC IINM KARN YLQS LPSK TKVA WAKL FPKS D/LN SKGY TKSI DIWS VGCI LAEM LSNR PIFP GKHY LDQL NHIL GILG SPSQ EDLN CIIN LKAR NYLL SLPH KNKV PWNR LFPN ADSK ALDL LDKM LTFN PHK |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | ERK; p38; p40; p41; ERK2; ERT1; NS13; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK |
Positive Sample: | K-562,Mouse brain,Mouse liver,Mouse spleen,Rat brain,Rat spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, centrosome, cytoskeleton, microtubule organizing center, spindle. |
Calculated MW: | 41kDa |
Observed MW: | 41kDa |
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5594 |
Clone Number: | ARC51159 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |