[KO Validated] ERCC1 Rabbit Polyclonal Antibody (CAB18066)
- SKU:
- CAB18066
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | [KO Validated] ERCC1 Rabbit Polyclonal Antibody |
SKU: | CAB18066 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human ERCC1 (NP_973730.1). |
Sequence: | MDPG KDKE GVPQ PSGP PARK KFVI PLDE DEVP PGVA KPLF RSTQ SLPT VDTS AQAA PQTY AEYA ISQP LEGA GATC PTGS EPLA GETP NQAL KPGA KSNS IIVS PRQR GNPV LKFV RNVP WEFG DVIP DYVL GQST CALF LSLR YHNL HPDY IHGR LQSL GKNF ALRV LLVQ VDVK DPQQ ALKE LAKM CILA DCTL ILAW SPEE AGRY LETY KAYE QKPA DLLM EKLE QDFV SRVT ECLT TVKS VNKT DSQT LLTT FGSL EQLI AASR EDLA LCPG LGPQ KVRA LGKN PRSW GKER APNK HNLR PQSF KVKK EPKT RHSG FRL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | UV20; COFS4; RAD10; C1 |
Positive Sample: | HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 33kDa |
Observed MW: | 38kDa |
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
Purification Method: | Affinity purification |
Gene ID: | 2067 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |