[KO Validated] HER2/ErbB2 Rabbit Polyclonal Antibody (CAB2071)
- SKU:
- CAB2071
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | [KO Validated] HER2/ErbB2 Rabbit Polyclonal Antibody |
SKU: | CAB2071 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1156-1255 of human HER2/ErbB2 (NP_004439.2). |
Sequence: | PTVP LPSE TDGY VAPL TCSP QPEY VNQP DVRP QPPS PREG PLPA ARPA GATL ERPK TLSP GKNG VVKD VFAF GGAV ENPE YLTP QGGA APQP HPPP AFSP AFDN LYYW DQDP PERG APPS TFKG TPTA ENPE YLGL DVPV |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IHC-P,1:50 - 1:200 |
Synonyms: | NEU; NGL; HER2; TKR1; CD340; HER-2; VSCN2; MLN 19; MLN-19; c-ERB2; c-ERB-2; HER-2/neu; p185(erbB2); HER2/ErbB2 |
Positive Sample: | SK-BR-3,Mouse lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Nucleus, Nucleus, Single-pass type I membrane protein, perinuclear region. |
Calculated MW: | 138kDa |
Observed MW: | 185kDa |
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
Purification Method: | Affinity purification |
Gene ID: | 2064 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |