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[KO Validated] HER2/ErbB2 Rabbit Polyclonal Antibody (CAB2071)

SKU:
CAB2071
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
  • KO Validated Antibodies 1 Anti-HER2 / ErbB2 Antibody CAB2071KO Validated
  • KO Validated Antibodies 1 Anti-HER2 / ErbB2 Antibody CAB2071KO Validated
  • KO Validated Antibodies 1 Anti-HER2 / ErbB2 Antibody CAB2071KO Validated
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] HER2/ErbB2 Rabbit Polyclonal Antibody
SKU:CAB2071
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1156-1255 of human HER2/ErbB2 (NP_004439.2).
Sequence:PTVP LPSE TDGY VAPL TCSP QPEY VNQP DVRP QPPS PREG PLPA ARPA GATL ERPK TLSP GKNG VVKD VFAF GGAV ENPE YLTP QGGA APQP HPPP AFSP AFDN LYYW DQDP PERG APPS TFKG TPTA ENPE YLGL DVPV
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:100 - 1:500 IHC-P,1:50 - 1:200
Synonyms:NEU; NGL; HER2; TKR1; CD340; HER-2; VSCN2; MLN 19; MLN-19; c-ERB2; c-ERB-2; HER-2/neu; p185(erbB2); HER2/ErbB2
Positive Sample:SK-BR-3,Mouse lung
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Cytoplasm, Nucleus, Nucleus, Single-pass type I membrane protein, perinuclear region.
Calculated MW:138kDa
Observed MW:185kDa

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Purification Method:Affinity purification
Gene ID:2064
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from SK-BR-3 cells, using HER2/ErbB2 Rabbit pAb (CAB2071) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.

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