[KO Validated] eIF4EBP1 Rabbit Polyclonal Antibody (CAB1248)
- SKU:
- CAB1248
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
Product Name: | [KO Validated] eIF4EBP1 Rabbit Polyclonal Antibody |
SKU: | CAB1248 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-118 of human eIF4EBP1 (NP_004086.1). |
Sequence: | TRII YDRK FLME CRNS PVTK TPPR DLPT IPGV TSPS SDEP PMEA SQSH LRNS PEDK RAGG EESQ FEMD I |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:100 - 1:200 |
Synonyms: | BP-1; 4EBP1; 4E-BP1; PHAS-I; eIF4EBP1 |
Positive Sample: | MCF7,HeLa,Mouse skeletal muscle |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol |
Calculated MW: | 13kDa |
Observed MW: | 15-20kDa |
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Purification Method: | Affinity purification |
Gene ID: | 1978 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |