[KO Validated] PKR/EIF2AK2 Rabbit Polyclonal Antibody (CAB5578)
- SKU:
- CAB5578
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | [KO Validated] PKR/EIF2AK2 Rabbit Polyclonal Antibody |
SKU: | CAB5578 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human PKR/EIF2AK2 (NP_002750.1). |
Sequence: | MAGD LSAG FFME ELNT YRQK QGVV LKYQ ELPN SGPP HDRR FTFQ VIID GREF PEGE GRSK KEAK NAAA KLAV EILN KEKK AVSP LLLT TTNS SEGL SMGN YIGL INRI AQKK RLTV NYEQ CASG VHGP EGFH YKCK MGQK EYSI GTGS TKQE AKQL AAKL AYLQ ILSE ETSV KSDY LSSG SFAT TCES QSNS LVTS TLAS ESSS EGDF SADT SEIN SNSD SLNS SSLL MNGL RNNQ RKAK RSLA PRFD LPDM KETK YTVD KRFG MDFK EI |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | PKR; PRKR; DYT33; LEUDEN; EIF2AK1; PPP1R83; PKR/EIF2AK2 |
Positive Sample: | HeLa,A-549 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus, perinuclear region. |
Calculated MW: | 62kDa |
Observed MW: | 69kDa |
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses.
Purification Method: | Affinity purification |
Gene ID: | 5610 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |