The DSG2 Polyclonal Antibody (CAB19996) is a crucial tool for researchers studying Desmoglein 2 (DSG2), a key protein involved in cell-cell adhesion and tissue integrity. This antibody, derived from rabbits, has been validated for its high specificity and sensitivity in detecting DSG2 in human samples using Western blot techniques.DSG2 is essential for maintaining the structure and function of epithelial tissues, particularly in the skin and heart. Mutations in the DSG2 gene have been linked to conditions like arrhythmogenic right ventricular cardiomyopathy (ARVC) and skin disorders.
By targeting DSG2 with this antibody, researchers can gain valuable insights into the role of DSG2 in disease pathogenesis and explore its potential as a therapeutic target.This antibody opens up opportunities for investigating the molecular mechanisms underlying DSG2-related diseases and may lead to the development of novel treatment strategies. Its application in immunology and cell biology research makes it a valuable asset for scientists striving to advance our understanding of tissue biology and pathology.
Product Name:
[KO Validated] DSG2 Rabbit Polyclonal Antibody
SKU:
CAB19996
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 635-935 of human DSG2 (NP_001934.2).
Cell junction, Cell membrane, Single-pass type I membrane protein, desmosome.
Calculated MW:
122kDa
Observed MW:
150kDa
This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. Mutations in this gene have been associated with arrhythmogenic right ventricular dysplasia, familial, 10.
Purification Method:
Affinity purification
Gene ID:
1829
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and DSG2 knockout (KO) A-549 cells, using [KO Validated] DSG2 Rabbit pAb (CAB19996) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
