[KO Validated] CRKL Rabbit Polyclonal Antibody (CAB11735)
- SKU:
- CAB11735
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | [KO Validated] CRKL Rabbit Polyclonal Antibody |
SKU: | CAB11735 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-303 of human CRKL (NP_005198.1). |
Sequence: | MSSA RFDS SDRS AWYM GPVS RQEA QTRL QGQR HGMF LVRD SSTC PGDY VLSV SENS RVSH YIIN SLPN RRFK IGDQ EFDH LPAL LEFY KIHY LDTT TLIE PAPR YPSP PMGS VSAP NLPT AEDN LEYV RTLY DFPG NDAE DLPF KKGE ILVI IEKP EEQW WSAR NKDG RVGM IPVP YVEK LVRS SPHG KHGN RNSN SYGI PEPA HAYA QPQT TTPL PAVS GSPG AAIT PLPS TQNG PVFA KAIQ KRVP CAYD KTAL ALEV GDIV KVTR MNIN GQWE GEVN GRKG LFPF THVK IFDP QNPD ENE |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CRKL |
Positive Sample: | LO2,Jurkat,SKOV3,Mouse brain,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, extrinsic component of postsynaptic membrane, neuromuscular junction, nucleoplasm |
Calculated MW: | 34kDa |
Observed MW: | 37kDa |
This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.
Purification Method: | Affinity purification |
Gene ID: | 1399 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |