[KO Validated] COMT Rabbit Polyclonal Antibody (CAB18085)
- SKU:
- CAB18085
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
Product Name: | [KO Validated] COMT Rabbit Polyclonal Antibody |
SKU: | CAB18085 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-221 of human COMT (NP_009294.1). |
Sequence: | VGDK KGKI VDAV IQEH QPSV LLEL GAYC GYSA VRMA RLLS PGAR LITI EINP DCAA ITQR MVDF AGVK DKVT LVVG ASQD IIPQ LKKK YDVD TLDM VFLD HWKD RYLP DTLL LEEC GLLR KGTV LLAD NVIC PGAP DFLA HVRG SSCF ECTH YQSF LEYR EVVD GLEK AIYK GPGS EAGP |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | HEL-S-98n; MT |
Positive Sample: | 293T |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Extracellular side, Single-pass type II membrane protein. |
Calculated MW: | 30kDa |
Observed MW: | 24kDa, 28kDa |
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
Purification Method: | Affinity purification |
Gene ID: | 1312 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |