The CNP Polyclonal Antibody (CAB18009) is a critical tool for researchers studying CNP, a key enzyme involved in the production of cyclic nucleotides which play vital roles in cell signaling. This antibody, produced in rabbits, has been rigorously validated for use in applications such as immunofluorescence, immunohistochemistry, and flow cytometry. It specifically targets the CNP protein, allowing for accurate detection and analysis in various tissues and cell types.CNP, also known as 2',3'-cyclic nucleotide 3'-phosphodiesterase, is essential for myelin synthesis in the central nervous system and has been implicated in neurological disorders such as multiple sclerosis and schizophrenia.
By targeting CNP with this antibody, researchers can gain valuable insights into the function and regulation of this enzyme, potentially leading to advancements in the treatment of these debilitating conditions. Additionally, the ability to accurately detect CNP expression in various tissues makes this antibody a valuable tool for drug discovery and development efforts targeting cyclic nucleotide signaling pathways.
Product Name:
[KO Validated] CNPase Rabbit Polyclonal Antibody
SKU:
CAB18009
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 152-421 of human CNPasease (NP_149124.3).
Predicted to enable 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity. Involved in substantia nigra development. Located in several cellular components, including extracellular space; microtubule; and plasma membrane. Implicated in hypomyelinating leukodystrophy 20; multiple sclerosis; and schizophrenia. Biomarker of alcoholic liver cirrhosis; multiple sclerosis; and restless legs syndrome.
Purification Method:
Affinity purification
Gene ID:
1267
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and CNPasease knockout (KO) HeLa cells, using [KO Validated] CNPase Rabbit pAb (CAB18009) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
