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[KO Validated] CDKN2C/p18-INK4C Rabbit Polyclonal Antibody (CAB18054)

SKU:
CAB18054
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Cycle
€139 - €419
Frequently bought together:

Description

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Product Name:[KO Validated] CDKN2C/p18-INK4C Rabbit Polyclonal Antibody
SKU:CAB18054
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-168 of human CDKN2C/p18-INK4C (NP_523240.1).
Sequence:MAEP WGNE LASA AARG DLEQ LTSL LQNN VNVN AQNG FGRT ALQV MKLG NPEI ARRL LLRG ANPD LKDR TGFA VIHD AARA GFLD TLQT LLEF QADV NIED NEGN LPLH LAAK EGHL RVVE FLVK HTAS NVGH RNHK GDTA CDLA RLYG RNEV VSLM QANG AGGA TNLQ
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:100
Synonyms:p18; INK4C; p18-INK4C; 4C
Positive Sample:HeLa
Conjugate:Unconjugated
Cellular Localization:cytoplasm, cytosol, nucleus
Calculated MW:18kDa
Observed MW:18kDa

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.

Purification Method:Affinity purification
Gene ID:1031
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from wild type (WT) and CDKN2C/p18-INK4C knockout (KO) HeLa cells, using [KO Validated] CDKN2C/p18-INK4C Rabbit pAb (CAB18054) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.

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