[KO Validated] CDK8 Rabbit Polyclonal Antibody (CAB5548)
- SKU:
- CAB5548
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | [KO Validated] CDK8 Rabbit Polyclonal Antibody |
SKU: | CAB5548 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 365-464 of human CDK8 (NP_001251.1). |
Sequence: | DDKG DKKN QQQQ QGNN HTNG TGHP GNQD SSHT QGPP LKKV RVVP PTTT SGGL IMTS DYQR SNPH AAYP NPGP STSQ PQSS MGYS ATSQ QPPQ YSHQ THRY |
Tested Applications: | WB IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | K35; IDDHBA; K8 |
Positive Sample: | Jurkat |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 53kDa |
Observed MW: | 56kDa |
This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 1024 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |