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[KO Validated] CDK5 Rabbit Polyclonal Antibody (CAB18080)

SKU:
CAB18080
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Death
$167 - $503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] CDK5 Rabbit Polyclonal Antibody
SKU:CAB18080
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 170-289 of human CDK5 (NP_004926.1).
Sequence:PDVL FGAK LYST SIDM WSAG CIFA ELAN AGRP LFPG NDVD DQLK RIFR LLGT PTEE QWPS MTKL PDYK PYPM YPAT TSLV NVVP KLNA TGRD LLQN LLKC NPVQ RISA EEAL QHPY FSDF
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:LIS7; PSSALRE; K5
Positive Sample:293T
Conjugate:Unconjugated
Cellular Localization:Cell junction, Cell membrane, Cell projection, Cytoplasm, Nucleus, Perikaryon, Peripheral membrane protein, growth cone, lamellipodium, postsynaptic cell membrane, postsynaptic density, synapse.
Calculated MW:33kDa
Observed MW:33kDa

This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:1020
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from wild type (WT) and CDK5 knockout (KO) 293T cells, using [KO Validated] CDK5 Rabbit pAb (CAB18080) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.

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