[KO Validated] CDK2AP1 Rabbit Polyclonal Antibody (CAB19985)
- SKU:
- CAB19985
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Description
Product Name: | [KO Validated] CDK2AP1 Rabbit Polyclonal Antibody |
SKU: | CAB19985 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-115 of human CDK2AP1 (NP_004633.1). |
Sequence: | MSYK PNLA AHMP AAAL NAAG SVHS PSTS MATS SQYR QLLS DYGP PSLG YTQG TGNS QVPQ SKYA ELLA IIEE LGKE IRPT YAGS KSAM ERLK RGII HARG LVRE CLAE TERN ARS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | DOC1; ST19; DORC1; doc-1; p12DOC-1; P1 |
Positive Sample: | 293T |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, nucleoplasm, nucleus, perinuclear region of cytoplasm |
Calculated MW: | 12kDa |
Observed MW: | 12kDa |
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method: | Affinity purification |
Gene ID: | 8099 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |