The KO Validated CD47 Rabbit Monoclonal Antibody is a powerful tool for researchers studying CD47, a key cell surface protein involved in immune regulation and cancer biology. This monoclonal antibody, generated in rabbits, is highly specific and sensitive for detecting CD47 in a variety of sample types. It has been rigorously tested and verified for use in Western blot applications, ensuring reliable and reproducible results.CD47 is known for its role in modulating immune responses, particularly in preventing the phagocytosis of cells by macrophages. Its dysregulation has been implicated in a variety of diseases, including cancer, making it an attractive target for therapeutic development.
By using this antibody, researchers can investigate the expression and function of CD47 in different cell types and gain valuable insights into its potential as a therapeutic target.In conclusion, the KO Validated CD47 Rabbit Monoclonal Antibody is a valuable tool for researchers interested in understanding the role of CD47 in immune regulation and disease pathogenesis. Its specificity, sensitivity, and reliability make it an essential reagent for studies in immunology, cancer biology, and beyond.
Product Name:
[KO Validated] CD47 Rabbit Monoclonal Antibody
SKU:
CAB11382
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 224-323 of human CD47 (Q08722).
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
961
Clone Number:
ARC0584
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CD47 antibody (CAB11382) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
