[KO Validated] Cyclin D3 Rabbit Polyclonal Antibody (CAB0746)
- SKU:
- CAB0746
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
Product Name: | [KO Validated] Cyclin D3 Rabbit Polyclonal Antibody |
SKU: | CAB0746 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 201-292 of human Cyclin D3 (NP_001751.1). |
Sequence: | SMIA TGSI GAAV QGLG ACSM SGDE LTEL LAGI TGTE VDCL RACQ EQIE AALR ESLR EASQ TSSS PAPK APRG SSSQ GPSQ TSTP TDVT AIHL |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CCND3; cyclin D3; Cyclin D3; D3 |
Positive Sample: | HeLa,K-562,Mouse spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Membrane, Nucleus. |
Calculated MW: | 33kDa |
Observed MW: | 36kDa |
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 896 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |