[KO Validated] HP1 gamma/CBX3 Rabbit Polyclonal Antibody (CAB2248)
- SKU:
- CAB2248
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | [KO Validated] HP1 gamma/CBX3 Rabbit Polyclonal Antibody |
SKU: | CAB2248 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-183 of human HP1 gamma/HP1 gamma/CBX3 (NP_009207.2). |
Sequence: | MASN KTTL QKMG KKQN GKSK KVEE AEPE EFVV EKVL DRRV VNGK VEYF LKWK GFTD ADNT WEPE ENLD CPEL IEAF LNSQ KAGK EKDG TKRK SLSD SESD DSKS KKKR DAAD KPRG FARG LDPE RIIG ATDS SGEL MFLM KWKD SDEA DLVL AKEA NMKC PQIV IAFY EERL TWHS CPED EAQ |
Tested Applications: | WB IHC-P IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | HECH; HP1-GAMMA; HP1Hs-gamma; X3 |
Positive Sample: | HeLa,MCF-7,293T,A-549,NCI-H460,Mouse brain,Mouse lung,Mouse spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 21kDa |
Observed MW: | 23kDa |
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 11335 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |