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[KO Validated] HP1 gamma/CBX3 Rabbit Polyclonal Antibody (CAB2248)

SKU:
CAB2248
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • KO Validated Antibodies 1 Anti-CBX3 Antibody CAB2248KO Validated
  • KO Validated Antibodies 1 Anti-CBX3 Antibody CAB2248KO Validated
  • KO Validated Antibodies 1 Anti-CBX3 Antibody CAB2248KO Validated
  • KO Validated Antibodies 1 Anti-CBX3 Antibody CAB2248KO Validated
  • KO Validated Antibodies 1 Anti-CBX3 Antibody CAB2248KO Validated
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] HP1 gamma/CBX3 Rabbit Polyclonal Antibody
SKU:CAB2248
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-183 of human HP1 gamma/HP1 gamma/CBX3 (NP_009207.2).
Sequence:MASN KTTL QKMG KKQN GKSK KVEE AEPE EFVV EKVL DRRV VNGK VEYF LKWK GFTD ADNT WEPE ENLD CPEL IEAF LNSQ KAGK EKDG TKRK SLSD SESD DSKS KKKR DAAD KPRG FARG LDPE RIIG ATDS SGEL MFLM KWKD SDEA DLVL AKEA NMKC PQIV IAFY EERL TWHS CPED EAQ
Tested Applications:WB IHC-P IF/ICC IP ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:HECH; HP1-GAMMA; HP1Hs-gamma; X3
Positive Sample:HeLa,MCF-7,293T,A-549,NCI-H460,Mouse brain,Mouse lung,Mouse spleen
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:21kDa
Observed MW:23kDa

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.

Purification Method:Affinity purification
Gene ID:11335
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using [KO Validated] HP1 gamma/CBX3 Rabbit pAb (CAB2248) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.

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