The KO Validated CD169 Polyclonal Antibody (CAB18018) is a key tool for researchers studying CD169, a cell surface receptor involved in immune response modulation. This rabbit-derived antibody is highly specific to human samples and has been rigorously validated for Western blot applications. By binding to the CD169 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential asset for studies in immunology and cancer research.CD169, also known as Siglec-1, plays a pivotal role in immune regulation by facilitating the uptake and presentation of pathogens to immune cells.
Its involvement in antiviral immune responses and antigen processing underscores its importance in understanding immune function and developing therapeutics. The CD169 Polyclonal Antibody is a valuable tool for uncovering the mechanisms by which CD169 influences immune responses, ultimately aiding in the development of targeted therapies for infectious diseases and immune-related disorders.
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene.
Purification Method:
Affinity purification
Gene ID:
847
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and Catalasealase knockout (KO) HeLa cells, using [KO Validated] Catalase Rabbit pAb (CAB18018) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
