The Calreticulin Polyclonal Antibody (CAB1066) is a key tool for researchers studying calreticulin, a multifunctional protein localized in the endoplasmic reticulum. Calreticulin is involved in various cellular processes such as calcium homeostasis, chaperone activity, and immune response regulation. This antibody, produced in rabbits, is highly specific to human calreticulin and is validated for Western blot applications.Calreticulin plays a crucial role in maintaining cellular homeostasis and has been implicated in diseases such as cancer and autoimmune disorders. By using this antibody, researchers can detect and analyze calreticulin expression in various cell types, shedding light on its function in different biological processes.
This insight is valuable for understanding the role of calreticulin in diseases and developing targeted therapies that modulate its activity.Overall, the Calreticulin Polyclonal Antibody (CAB1066) is a versatile tool for investigating calreticulin biology in research areas such as immunology, cancer, and cell biology. Its high specificity and reliability make it an essential resource for scientists seeking to unravel the complex functions of calreticulin in health and disease.
Product Name:
Calreticulin Polyclonal Antibody
SKU:
CAB1066
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 18-203 of human Calreticulineticulin (NP_004334.1).
Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.
Purification Method:
Affinity purification
Gene ID:
811
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Calreticulin Rabbit pAb (CAB1066) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
