[KO Validated] CAST Rabbit Polyclonal Antibody (CAB7634)
- SKU:
- CAB7634
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | [KO Validated] CAST Rabbit Polyclonal Antibody |
SKU: | CAB7634 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 510-610 of human CAST (NP_001177371.1). |
Sequence: | QNAS SLKF EDAK LAAA ISEV VSQT PAST TQAG APPR DTSQ SDKD LDDA LDKL SDSL GQRQ PDPD ENKP MEDK VKEK AKAE HRDK LGER DDTI PPEY RHLL D |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | BS-17; PLACK; ST |
Positive Sample: | A-549,SW480,MCF-7,HepG2,Mouse lung,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | cytoplasm, cytosol, endoplasmic reticulum |
Calculated MW: | 77kDa |
Observed MW: | 130kDa |
The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described.
Purification Method: | Affinity purification |
Gene ID: | 831 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |