The c-Myc Rabbit Monoclonal Antibody (CAB19032) is a highly specific tool for research involving the c-Myc protein, a key regulator of cell proliferation, differentiation, and apoptosis. This antibody, derived from rabbits, exhibits strong reactivity with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.The c-Myc protein is a transcription factor with important roles in various cellular processes, including cell cycle progression and metabolism. Dysregulation of c-Myc expression is implicated in numerous diseases, particularly cancer, making it a prominent target for therapeutic intervention.
By detecting and quantifying c-Myc levels in different cell types, this antibody enables detailed analysis of its function and potential as a biomarker in cancer research and drug development.Understanding the intricate mechanisms of c-Myc activity is crucial for advancing knowledge in oncology and identifying novel treatment strategies. With its high specificity and sensitivity, the c-Myc Rabbit Monoclonal Antibody (CAB19032) is a valuable tool for scientists seeking to unravel the complexities of c-Myc signaling pathways and their implications in disease progression.
Product Name:
[KO Validated] c-Myc Rabbit Monoclonal Antibody
SKU:
CAB19032
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human c-Myc (P01106).
WB,1:500 - 1:1000 ChIP,5μg antibody for 10μg-15μg of ChromatinCUT&Tag, 10⁵ cells /1 μg
Synonyms:
MRTL; MYCC; c-Myc; bHLHe39; yc
Positive Sample:
Jurkat, MCF7, HCT 116, Mouse ovary
Conjugate:
Unconjugated
Cellular Localization:
Nucleus, nucleolus, nucleoplasm.
Calculated MW:
51kDa
Observed MW:
50-60kDa
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.
Purification Method:
Affinity purification
Gene ID:
4609
Clone Number:
ARC0412
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
UT&Tag was performed using the CUT&Tag Assay Kit (pAG-Tn5) for Illumina(RK20265) from 10⁵ K562 cells with 1μg c-Myc Rabbit mAb(CAB19032), along with a Goat Anti-Rabbit IgG(H+L). The CUT&Tag results indicate the enrichment pattern of ESE1 in representative gene loci (NPM1), as shown in figure.
