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[KO Validated] c-Myc Rabbit Monoclonal Antibody (CAB19032)

SKU:
CAB19032
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
  • KO Validated Antibodies 2 Anti-c-Myc Antibody KO Validated CAB19032
  • KO Validated Antibodies 2 Anti-c-Myc Antibody KO Validated CAB19032
  • KO Validated Antibodies 2 Anti-c-Myc Antibody KO Validated CAB19032
  • KO Validated Antibodies 2 Anti-c-Myc Antibody KO Validated CAB19032
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] c-Myc Rabbit Monoclonal Antibody
SKU:CAB19032
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human c-Myc (P01106).
Sequence:MPLN VSFT NRNY DLDY DSVQ PYFY CDEE ENFY QQQQ QSEL QPPA PSED IWKK FELL PTPP LSPS RRSG LCSP SYVA VTPF SLRG DNDG GGGS FSTA DQLE
Tested Applications:WB ChIP ELISA CUT&Tag
Recommended Dilution:WB,1:500 - 1:1000 ChIP,5μg antibody for 10μg-15μg of ChromatinCUT&Tag, 10⁵ cells /1 μg
Synonyms:MRTL; MYCC; c-Myc; bHLHe39; yc
Positive Sample:Jurkat, MCF7, HCT 116, Mouse ovary
Conjugate:Unconjugated
Cellular Localization:Nucleus, nucleolus, nucleoplasm.
Calculated MW:51kDa
Observed MW:50-60kDa

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.

Purification Method:Affinity purification
Gene ID:4609
Clone Number:ARC0412
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageUT&Tag was performed using the CUT&Tag Assay Kit (pAG-Tn5) for Illumina(RK20265) from 10⁵ K562 cells with 1μg c-Myc Rabbit mAb(CAB19032), along with a Goat Anti-Rabbit IgG(H+L). The CUT&Tag results indicate the enrichment pattern of ESE1 in representative gene loci (NPM1), as shown in figure.

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