[KO Validated] β-Catenin Rabbit Monoclonal Antibody (CAB19657)
- SKU:
- CAB19657
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | [KO Validated] β-Catenin Rabbit Monoclonal Antibody |
SKU: | CAB19657 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human beta Catenin (P35222). |
Sequence: | MATQ ADLM ELDM AMEP DRKA AVSH WQQQ SYLD SGIH SGAT TTAP SLSG KGNP EEED VDTS QVLY EWEQ GFSQ SFTQ EQVA DIDG QYAM TRAQ RVRA AMFP |
Tested Applications: | WB IHC-P IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 400μg-600μg extracts of whole cells |
Synonyms: | EVR7; CTNNB; MRD19; NEDSDV; armadillo; in |
Positive Sample: | HeLa cells,293T cells,NIH/3T3 cells,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Cytoplasm, Nucleus, adherens junction, centrosome, cytoskeleton, microtubule organizing center, spindle pole. |
Calculated MW: | 85kDa |
Observed MW: | 92kDa |
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 1499 |
Clone Number: | ARC0136 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |