The Beclin-1 Polyclonal Antibody is a valuable tool for researchers studying autophagy and cell survival pathways. Raised in rabbits, this antibody is highly specific for the Beclin-1 protein and is validated for use in immunohistochemistry and Western blot applications. Beclin-1 is a key regulator of autophagy, a cellular process that plays a critical role in maintaining cellular homeostasis and protecting against various diseases, including cancer and neurodegenerative disorders. By targeting Beclin-1 with this antibody, researchers can investigate the role of autophagy in disease progression and develop targeted therapies to modulate this pathway.
This antibody is ideal for studies in cancer research, neurology, and cell biology, providing researchers with a reliable tool to investigate the mechanisms of autophagy and its implications for human health. Its high specificity and sensitivity make it a valuable asset for any laboratory conducting research in these areas.
This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
8678
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Beclin 1 Rabbit pAb (CAB11761) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
