The KO Validated BCL10 Polyclonal Antibody (CAB1106) is a vital tool for research involving BCL10, a protein involved in the activation of the NF-κB signaling pathway. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the BCL10 protein, researchers can accurately detect and analyze its expression in various cell types.BCL10 is a key player in immune signaling pathways, regulating processes such as cell survival and inflammation. Dysregulation of BCL10 has been linked to various diseases, including lymphoma and inflammatory disorders.
Therefore, studying the function and expression of BCL10 is crucial for understanding the molecular mechanisms underlying these conditions and developing targeted therapies.The KO Validated BCL10 Polyclonal Antibody is a valuable tool for researchers investigating the role of BCL10 in immune responses, inflammation, and cancer development. Its specificity and reliability make it an essential component of immunology and oncology research projects.
Product Name:
[KO Validated] Bcl10 Rabbit Polyclonal Antibody
SKU:
CAB1106
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-233 of human Bcl10 (NP_003912.1).
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
8915
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and Bcl10 knockout (KO) HeLa cells, using [KO Validated] Bcl10 Rabbit pAb (CAB1106) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
