The KO Validated Bax Rabbit Monoclonal Antibody (CAB19684) is a powerful tool for researchers studying the Bax protein, a key player in the regulation of apoptosis (cell death). This antibody, raised in rabbits, is highly specific and sensitive when detecting Bax in human samples, making it ideal for use in Western blot applications.Bax is a pro-apoptotic protein that plays a crucial role in determining cell fate and has been implicated in various diseases, including cancer.
By targeting Bax with this validated antibody, researchers can gain valuable insights into the mechanisms of apoptosis and potentially identify novel therapeutic targets for cancer treatment.The use of the KO Validated Bax Rabbit Monoclonal Antibody in research involving apoptosis, cancer biology, and drug development is sure to yield significant advancements in our understanding of cell death pathways and their implications for human health.
Product Name:
[KO Validated] Bax Rabbit Monoclonal Antibody
SKU:
CAB19684
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Bax (Q07812).
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. The association and the ratio of BAX to BCL2 also determines survival or death of a cell following an apoptotic stimulus. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
Purification Method:
Affinity purification
Gene ID:
581
Clone Number:
ARC0164
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Bax Rabbit mAb (CAB19684) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
