[KO Validated] BAG2 Rabbit Polyclonal Antibody (CAB19945)
- SKU:
- CAB19945
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
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Description
Product Name: | [KO Validated] BAG2 Rabbit Polyclonal Antibody |
SKU: | CAB19945 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-211 of human BAG2 (NP_004273.1). |
Sequence: | MAQA KINA KANE GRFC RSSS MADR SSRL LESL DQLE LRVE ALRE AATA VEQE KEIL LEMI HSIQ NSQD MRQI SDGE REEL NLTA NRLM GRTL TVEV SVET IRNP QQQE SLKH ATRI IDEV VNKF LDDL GNAK SHLM SLYS ACSS EVPH GPVD QKFQ SIVI GCAL EDQK KIKR RLET LLRN IENS DKAI KLLE HSKG AGSK TLQQ NAES RFN |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | BAG-2; dJ417I1.2; G2 |
Positive Sample: | HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | axon, cytosol, dendrite, dendritic microtubule |
Calculated MW: | 24kDa |
Observed MW: | 24kDa |
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
Purification Method: | Affinity purification |
Gene ID: | 9532 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |