The B2M Polyclonal Antibody (CAB12404) is a specialized tool for investigating B2M, a crucial component of the major histocompatibility complex (MHC) class 1 molecules. This antibody is produced in rabbits and specifically targets human samples, making it a reliable choice for Western blot applications. By binding to the B2M protein, researchers can accurately assess its presence and function in a variety of cell types, making it an essential resource for studies in immunology and cancer research.B2M is involved in presenting antigens to T cells, playing a pivotal role in immune surveillance and response.
Its involvement in the MHC class 1 pathway makes it an appealing target for investigating diseases like cancer, autoimmune disorders, and viral infections. By understanding the function of B2M, researchers can uncover potential therapeutic strategies that manipulate immune responses for improved health outcomes.Overall, the B2M Polyclonal Antibody (CAB12404) offers a valuable tool for exploring the roles of B2M in immune function and disease, paving the way for new insights and advancements in biomedical research.
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.
Purification Method:
Affinity purification
Gene ID:
567
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using beta 2 Microglobulin Rabbit pAb (CAB12404) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
