The ARHGDIA Polyclonal Antibody (CAB1214) is a valuable tool for research involving ARHGDIA, a protein involved in regulating cell signaling and cytoskeletal dynamics. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to ARHGDIA, this antibody allows for the detection and analysis of this important protein in a variety of cell types.ARHGDIA, also known as Rho GDP-dissociation inhibitor 1, plays a crucial role in regulating the activity of Rho GTPases, which are key regulators of cell migration, proliferation, and cytoskeletal organization.
Dysregulation of ARHGDIA has been implicated in various diseases, including cancer and neurological disorders. By studying ARHGDIA, researchers can gain insights into the molecular mechanisms underlying these conditions and potentially develop targeted therapies.Overall, the ARHGDIA Polyclonal Antibody (CAB1214) is a versatile tool for studying the function and regulation of ARHGDIA in various biological processes, making it an essential component of research in cell biology, cancer biology, and neuroscience.
Product Name:
[KO Validated] RhoGDI Rabbit Polyclonal Antibody
SKU:
CAB1214
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-204 of human RhoGDI (NP_001172006.1).
This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
396
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts from normal (control) and RhoGDI knockout (KO) 293T cells, using RhoGDI antibody (CAB1214) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
