The KO-Validated APEX1 Polyclonal Antibody (CAB2587) is a powerful tool for researchers studying APEX1, a multifunctional protein involved in DNA repair and redox regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been rigorously validated for Western blot applications.APEX1, also known as redox factor-1, plays a crucial role in maintaining genomic integrity and cellular homeostasis by repairing DNA damage caused by oxidative stress. Its involvement in these essential processes makes it a key target for research in fields such as cancer biology, neurodegeneration, and aging.
The APEX1 Polyclonal Antibody binds specifically to the APEX1 protein, allowing for accurate detection and analysis in a variety of cell types. Its reliability and specificity make it an ideal tool for investigating the role of APEX1 in DNA repair mechanisms and cellular responses to oxidative stress. Researchers can use this antibody to further our understanding of APEX1 function and its potential implications for human health and disease.
The APEX gene encodes the major AP endonuclease in human cells. It encodes the APEX endonuclease, a DNA repair enzyme with apurinic/apyrimidinic (AP) activity. Such AP activity sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. The AP sites are the most frequent pre-mutagenic lesions that can prevent normal DNA replication. Splice variants have been found for this gene; all encode the same protein. Disruptions in the biological functions related to APEX are associated with many various malignancies and neurodegenerative diseases.
Purification Method:
Affinity purification
Gene ID:
328
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] APEX1/APE1 Rabbit pAb (CAB2587).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
