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[KO Validated] APEX1/APE1 Rabbit Polyclonal Antibody (CAB2587)

SKU:
CAB2587
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
  • KO Validated Antibodies 1 Anti-APEX1 Antibody CAB2587KO Validated
  • KO Validated Antibodies 1 Anti-APEX1 Antibody CAB2587KO Validated
  • KO Validated Antibodies 1 Anti-APEX1 Antibody CAB2587KO Validated
  • KO Validated Antibodies 1 Anti-APEX1 Antibody CAB2587KO Validated
  • KO Validated Antibodies 1 Anti-APEX1 Antibody CAB2587KO Validated
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] APEX1/APE1 Rabbit Polyclonal Antibody
SKU:CAB2587
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-318 of human APEX1/APE1 (NP_542380.1).
Sequence:MPKR GKKG AVAE DGDE LRTE PEAK KSKT AAKK NDKE AAGE GPAL YEDP PDQK TSPS GKPA TLKI CSWN VDGL RAWI KKKG LDWV KEEA PDIL CLQE TKCS ENKL PAEL QELP GLSH QYWS APSD KEGY SGVG LLSR QCPL KVSY GIGD EEHD QEGR VIVA EFDS FVLV TAYV PNAG RGLV RLEY RQRW DEAF RKFL KGLA SRKP LVLC GDLN VAHE EIDL RNPK GNKK NAGF TPQE RQGF GELL QAVP LADS FRHL YPNT PYAY TFWT YMMN ARSK NVGW RLDY FLLS HSLL PALC DSKI RSKA LGSD HCPI TLYL AL
Tested Applications:WB IF/ICC IP ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:100 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:APE; APX; APE1; APEN; APEX; HAP1; REF1; E1
Positive Sample:HeLa,HepG2
Conjugate:Unconjugated
Cellular Localization:Cytoplasm, Endoplasmic reticulum, Mitochondrion, Nucleus, Nucleus speckle, nucleolus.
Calculated MW:36kDa
Observed MW:39kDa

The APEX gene encodes the major AP endonuclease in human cells. It encodes the APEX endonuclease, a DNA repair enzyme with apurinic/apyrimidinic (AP) activity. Such AP activity sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. The AP sites are the most frequent pre-mutagenic lesions that can prevent normal DNA replication. Splice variants have been found for this gene; all encode the same protein. Disruptions in the biological functions related to APEX are associated with many various malignancies and neurodegenerative diseases.

Purification Method:Affinity purification
Gene ID:328
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using [KO Validated] APEX1/APE1 Rabbit pAb (CAB2587).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.

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