[KO Validated] Annexin A5/Annexin V Rabbit Polyclonal Antibody (CAB1728)
The KO Validated Annexin A5 Polyclonal Antibody (CAB1728) is a key tool for researchers studying Annexin A5, a protein involved in cell membrane dynamics and apoptosis. This antibody, produced in rabbits, is highly specific for human samples and has been rigorously validated for use in Western blot applications.Annexin A5 is a calcium-dependent phospholipid-binding protein that plays a crucial role in membrane trafficking, cell signaling, and cell death pathways. It is implicated in various cellular processes, including clotting, inflammation, and cancer progression.
The KO Validated Annexin A5 Polyclonal Antibody enables precise detection and analysis of Annexin A5 in different cell types, making it ideal for investigations in cell biology, apoptosis, and cancer research.Understanding the functions and regulation of Annexin A5 is essential for unraveling its role in health and disease. This antibody provides a reliable tool for studying Annexin A5 in diverse experimental settings, shedding light on its potential as a therapeutic target in conditions such as cancer, cardiovascular disease, and neurodegenerative disorders.
Product Name:
[KO Validated] Annexin A5/Annexin V Rabbit Polyclonal Antibody
SKU:
CAB1728
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human Annexin A5/Annexin V (NP_001145.1).
PP4; ANX5; ENX2; CPB-I; RPRGL3; HEL-S-7; VAC-alph; V
Positive Sample:
HepG2,HeLa,DU145,PC-3,Mouse lung
Conjugate:
Unconjugated
Cellular Localization:
cytoplasm, cytosol, external side of plasma membrane, extracellular exosome, extracellular region, focal adhesion
Calculated MW:
36kDa
Observed MW:
35kDa
The Annexin 5 gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. Polymorphisms in this gene have been implicated in various obstetric complications.
Purification Method:
Affinity purification
Gene ID:
308
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Annexin A5/Annexin V antibody (CAB1728) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
