The KO Validated Alpha Catenin Rabbit Monoclonal Antibody (CAB19004) is a cutting-edge tool for researchers studying alpha catenin, a key protein involved in cell-cell adhesion and signaling pathways. This high-quality antibody, generated in rabbits, demonstrates strong reactivity with knockout (KO) samples and has been rigorously validated for various applications, including immunofluorescence and immunoprecipitation.Alpha catenin plays a crucial role in maintaining tissue integrity and regulating cell migration, making it a central player in processes like embryonic development and wound healing.
Dysregulation of alpha catenin has been linked to various diseases, including cancer and cardiovascular disorders, underscoring the importance of studying this protein in different biological contexts.With its specificity and reliability, the KO Validated Alpha Catenin Rabbit Monoclonal Antibody (CAB19004) is an invaluable tool for researchers seeking to unravel the complexities of cell adhesion mechanisms and the role of alpha catenin in health and disease. Its superior performance and versatility make it a must-have reagent for studies in cell biology, molecular biology, and beyond.
This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy.
Purification Method:
Affinity purification
Gene ID:
1495
Clone Number:
ARC0348
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts from wild type (WT) and α-Catenin knockout (KO) 293T cells, using α-Catenin antibody (CAB19004) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
