The AKR1A1 Polyclonal Antibody (CAB18014) is a valuable tool for researchers studying AKR1A1, an enzyme involved in the metabolism of various endogenous and exogenous substrates. This rabbit polyclonal antibody has been validated for use in various research applications, including Western blotting, immunohistochemistry, and immunofluorescence.AKR1A1, also known as aldo-keto reductase family 1 member A1, plays a crucial role in the detoxification of reactive carbonyls and the reduction of lipid peroxidation products. Dysregulation of AKR1A1 has been implicated in various diseases, including cancer, diabetes, and neurodegenerative disorders.
By using this antibody, researchers can study the expression and function of AKR1A1 in different cell types and tissues, providing insights into its role in disease development and progression.Overall, the AKR1A1 Polyclonal Antibody (CAB18014) is a reliable tool for researchers seeking to investigate the physiological and pathological functions of AKR1A1, with the potential to contribute to the development of new therapeutic strategies targeting this enzyme.
Product Name:
[KO Validated] AKR1A1 Rabbit Polyclonal Antibody
SKU:
CAB18014
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-325 of human AKR1A1 (NP_006057.1).
apical plasma membrane, cytosol, extracellular exosome, extracellular space
Calculated MW:
37kDa
Observed MW:
36kDa
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein.
Purification Method:
Affinity purification
Gene ID:
10327
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and AKR1A1 knockout (KO) 293T cells, using [KO Validated] AKR1A1 Rabbit pAb (CAB18014) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
