The AK2 Polyclonal Antibody (CAB6519) is a highly specific and sensitive tool for studying AK2, a key enzyme involved in cellular energy metabolism. This antibody, raised in rabbits, has been validated for use in various research applications, including Western blot and immunohistochemistry.AK2 is a crucial protein that plays a vital role in the maintenance of mitochondrial function and energy production within cells. Dysregulation of AK2 has been linked to various diseases, including metabolic disorders, neurodegenerative diseases, and cancer. Therefore, studying AK2 expression and activity is essential for understanding its impact on cellular physiology and disease progression.
The AK2 Polyclonal Antibody (CAB6519) allows for specific detection and analysis of AK2 protein levels in different cell types and tissues, making it an invaluable tool for researchers in the fields of biochemistry, cell biology, and medical research. By targeting AK2 with this antibody, researchers can gain valuable insights into the molecular mechanisms underlying disease pathology and potentially identify new therapeutic targets for intervention.
Product Name:
[KO Validated] AK2 Rabbit Polyclonal Antibody
SKU:
CAB6519
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-232 of human AK2 (NP_001616.1).
Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.
Purification Method:
Affinity purification
Gene ID:
204
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] AK2 Rabbit pAb (CAB6519) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
