The AIFM1 Polyclonal Antibody (CAB2568) is a valuable tool for researchers studying apoptosis-inducing factor, mitochondrion-associated 1 (AIFM1) in the context of cell death and mitochondrial function. This antibody, produced in rabbits, has been rigorously validated for Western blot applications and shows high specificity for human samples.AIFM1 is a key regulator of apoptosis, playing a pivotal role in the execution of programmed cell death. Dysregulation of AIFM1 has been implicated in various diseases, including neurodegenerative disorders and cancer, making it a crucial target for investigation in biomedical research.
The AIFM1 Polyclonal Antibody enables accurate detection and analysis of AIFM1 protein levels in different cell types, providing insights into its function and potential therapeutic applications.By utilizing the AIFM1 Polyclonal Antibody in their experiments, researchers can further elucidate the intricate mechanisms underlying apoptosis and mitochondrial dynamics, paving the way for the development of novel diagnostics and treatments for AIFM1-related conditions.
Product Name:
[KO Validated] AIF Rabbit Polyclonal Antibody
SKU:
CAB2568
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 334-613 of human AIF (NP_004199.1).
This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and cognitive disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.
Purification Method:
Affinity purification
Gene ID:
9131
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] AIF Rabbit pAb (CAB2568) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
