The ADK Polyclonal Antibody (CAB19992) is a powerful tool for researchers studying Adenosine Kinase (ADK), an enzyme involved in regulating levels of adenosine, a key molecule in various physiological processes. This antibody, generated in rabbits, is highly specific and validated for use in applications such as Western blot and immunohistochemistry.ADK plays a crucial role in regulating the adenosine signaling pathway, which is involved in modulating inflammation, neuronal excitability, and neurotransmission. Dysregulation of ADK has been implicated in various diseases, including epilepsy, neurodegenerative disorders, and cancer.
By detecting and analyzing ADK levels in different cell types, this antibody aids in understanding the role of ADK in these conditions.With its high reactivity towards human samples, the ADK Polyclonal Antibody is an essential tool for researchers in the fields of neuroscience, cancer biology, and pharmacology. By elucidating the functions of ADK, this antibody contributes to the development of novel therapeutic strategies targeting adenosine signaling pathways for the treatment of various diseases.
Product Name:
[KO Validated] ADK Rabbit Polyclonal Antibody
SKU:
CAB19992
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 200-345 of human ADK (NP_001114.2).
This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
132
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and ADK knockout (KO) HeLa cells, using [KO Validated] ADK Rabbit pAb (CAB19992) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
