[KO Validated] active + pro Caspase-3 Rabbit Monoclonal Antibody (CAB19654)
- SKU:
- CAB19654
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | [KO Validated] active + pro Caspase-3 Rabbit Monoclonal Antibody |
SKU: | CAB19654 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-175 of human Caspase-3 (P42574). |
Sequence: | SGIS LDNS YKMD YPEM GLCI IINN KNFH KSTG MTSR SGTD VDAA NLRE TFRN LKYE VRNK NDLT REEI VELM RDVS KEDH SKRS SFVC VLLS HGEE GIIF GTNG PVDL KKIT NFFR GDRC RSLT GKPK LFII QACR GTEL DCGI ETD |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | CPP32; SCA-1; CPP32B; -3 |
Positive Sample: | 293T,Jurkat,L929,NIH/3T3,Mouse lung,Mouse liver,Rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm |
Calculated MW: | 32kDa |
Observed MW: | 17kDa/32kDa/35kDa |
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.
Purification Method: | Affinity purification |
Gene ID: | 836 |
Clone Number: | ARC0133 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |