The Acetyl-HMGB1 K29 Polyclonal Antibody (CAB16002) is a valuable tool for researchers studying post-translational modifications of the HMGB1 protein. This antibody, raised in rabbits and validated for use in various applications including Western blot and immunohistochemistry, specifically targets the acetylated form of HMGB1 at lysine 29.HMGB1 is a highly conserved nuclear protein implicated in a variety of cellular processes, including DNA repair, transcriptional regulation, and inflammation. Acetylation of HMGB1 at specific residues, such as lysine 29, has been shown to modulate its functions and interactions with other proteins, leading to diverse cellular responses.
The Acetyl-HMGB1 K29 Polyclonal Antibody enables researchers to study the role of acetylated HMGB1 in different cellular contexts, providing insight into its function in processes such as immune response, autophagy, and apoptosis. By targeting this specific post-translational modification, researchers can gain a deeper understanding of HMGB1 biology and its implications in disease states such as cancer, autoimmune disorders, and inflammatory conditions.
This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein.
Purification Method:
Affinity purification
Gene ID:
3146
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunofluorescence analysis of C6 cells using Acetyl-HMGB1-K29 Rabbit pAb (CAB16002) at dilution of 1:100 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
