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[KO/KD Validated]MyD88 Rabbit Monoclonal Antibody (CAB22600)

SKU:
CAB22600
$167
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Description

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Product Name:[KO/KD Validated]MyD88 Rabbit Monoclonal Antibody
SKU:CAB22600
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human MyD88 (NP_002459.3).
Sequence:LAEE MDFE YLEI RQLE TQAD PTGR LLDA WQGR PGAS VGRL LELL TKLG RDDV LLEL GPSI EEDC QKYI LKQQ QEEA EKPL QVAA VDSS VPRT AELA GITT L
Tested Applications:WB ELISA
Recommended Dilution:WB,1:2000 - 1:9000
Synonyms:WM1; IMD68; MYD88D
Positive Sample:A549,HeLa,Mouse lung,Mouse heart
Conjugate:Unconjugated
Cellular Localization:Cytoplasm.
Calculated MW:33kDa
Observed MW:33kDa

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:4615
Clone Number:ARC52507_ARC52509
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates, using MyD88 Rabbit PolymAb® (CAB22600) at 1:8000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.

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