[KO/KD Validated] MCM6 Monoclonal Antibody (CAB21112)
- SKU:
- CAB21112
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
Product Name: | [KO/KD Validated] MCM6 Monoclonal Antibody |
SKU: | CAB21112 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 601-821 of human MCM6 (NP_005906.2). |
Sequence: | LRQR DGSG VTKS SWRI TVRQ LESM IRLS EAMA RMHC CDEV QPKH VKEA FRLL NKSI IRVE TPDV NLDQ EEEI QMEV DEGA GGIN GHAD SPAP VNGI NGYN EDIN QESA PKAS LRLG FSEY CRIS NLIV LHLR KVEE EEDE SALK RSEL VNWY LKEI ESEI DSEE ELIN KKRI IEKV IHRL THYD HVLI ELTQ AGLK GSTE GSES YEED PYLV VNPN YLLE D |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | Mis5; P105MCM; MCG40308; [KO/KD Validated] MCM6 |
Positive Sample: | 293T,HeLa,Jurkat,Mouse testis |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 93kDa |
Observed MW: | 93kDa |
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood.
Purification Method: | Affinity purification |
Gene ID: | 4175 |
Clone Number: | ARC3057 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |