The KMT5C Polyclonal Antibody (CAB16235) is a specialized research tool for studying KMT5C, a protein with important roles in regulating gene expression and chromatin structure. This antibody, produced in rabbits, exhibits high specificity and sensitivity for detecting KMT5C in human samples, making it a valuable asset for researchers conducting Western blot experiments.KMT5C, also known as lysine methyltransferase 5C, is involved in modifying histone proteins, thereby influencing gene transcription and cell function. Aberrant KMT5C activity has been linked to various diseases, including cancer and developmental disorders.
By utilizing this antibody to visualize and analyze KMT5C levels in different cell types, researchers can gain insights into its biological functions and potential therapeutic targets.With its reliability and versatility in detecting KMT5C, the CAB16235 antibody is an essential tool for investigations in the fields of epigenetics, gene regulation, and oncology research. Its use can aid in unraveling the complex mechanisms underlying disease development and progression, paving the way for the development of novel treatment strategies.
Product Name:
[KO Validated] KMT5C Rabbit Polyclonal Antibody
SKU:
CAB16235
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human KMT5C (NP_116090.2).
Sequence:
FLPE SGFT ILPC TRYS METN GAKI VSTR AWKK NEKL ELLV GCIA ELRE ADEG LLRA GEND FSIM YSTR KRSA QLWL GPAA FINH DCKP NCKF VPAD GNAA C
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:500 - 1:1000
Synonyms:
SUV420H2; Suv4-20h2; 5C
Positive Sample:
HeLa,293T,Jurkat,Mouse thymus
Conjugate:
Unconjugated
Cellular Localization:
Chromosome, Nucleus.
Calculated MW:
52kDa
Observed MW:
52kDa
SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).
Purification Method:
Affinity purification
Gene ID:
84787
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KO Validated] KMT5C Rabbit pAb (CAB16235) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
